The researchers have proved the anti-tumor effects of the drug on immunodeficient mice.
The new compound and its derivatives enabled the researchers to reduce tumor activity by 50 percent after 41 days of treatment with the drugadministered twice a week, to mice with induced tumors. They have also managed to successfully describe the mechanisms by which the drug acts on the ovarian cancer treatments stem cells CSCs.
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The Córdoba-based company Canvax Biotech has also participated in the development of the patent. A non-toxic drug One of the major advantages of the drug is that it is non-toxic. Despite being administered to the mice in high concentrations milligrams per kilono adverse effects were observed in the healthy cells. Moreover, from a pharmaceutical perspective this anti-tumor drug can be successfully produced in large quantities.
Totuşi, se remarcă faptul că în toate aceste cazuri, pacienţii vârstnici primesc un tratament sun nivelul optim din cauza temerilor legate de complicaţii. Este nevoie de continuarea studiilor pentru acest grup de populație, pentru a se evalua cât mai corect doza necesară de tratament, cât şi toxicitatea şi posibilele interacţiuni ale comorbidităților aferente. Nu trebuie neglijat nici suportul psihologic şi social de care aceşti pacienţi au nevoie.
The researchers were able to obtain the required amount of the synthesis in just five days. In the initial phases of their research, the scientists had already managed to create an effective drug called Bozepinib for treating cancer stem cellsbut the process involved in its chemical synthesis was lengthy and required a great deal of time to produce very small quantities of the drug.
Having completed structural modifications of the drug—Bozepinib by making changes ovarian cancer treatments its molecular architecturethey have successfully created a compound which maintains the biological activity of its predecessor as an effective anti-tumor drug, but which can also be synthesized and produced on a grand scale—a fundamental condition for the drug's commercial development.
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In order to be able to test the new drug on mice and gauge its effectiveness on human tumors, first of all they had to inject human tumor cells into immunodeficient mice to ensure they did not reject these cancerous cells. Following the treatment, they discovered that some of the compounds effectively inhibited the growth of the tumor cells and ovarian cancer treatments migration ability of these cells to other healthy tissues, considerably diminishing the likelihood of metastasis.
MANAGEMENT OF BORDERLINE OVARIAN TUMORS
The drug directly targets CSCs without affecting the healthy cellsa huge advantagewhen compared to other cancer treatments such as chemotherapy. AlthoughCSCs are only found in small quantities in tumors, from a clinical perspective the ability to target them directly is of fundamental importance, given that they are responsible for originally causing the tumor, relapses and resistance to anticancer treatments.
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The next step: Lungs and pancreas Having proved the pre-clinical effectiveness of the new drug in treating cancer stem cells in breast, colon, and skin cancers, the scientists will now proceed to study the drug's effect on lung and pancreas cancers, two of the most aggressive types. They must also complete further ADME-Tox "absorption, distribution, metabolism, excretion and toxicity" studies of the compound's behavior within the organism, a necessary step before carrying out clinical trials.
García-Rubiño, M. Núñez-Carretero, D. Choquesillo-Lazarte, J.
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García-Ruiz, Yolanda Madrid, J. Campos, Ana Sánchez, María A. García, Juan A.
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