Clujul Med ; 86 1 : Many types of FG are manufactured for specific uses building insulation, air handling, and sound absorption. Because of increasing use and potential for widespread human exposure, a chronic toxicity instillation study was conducted in Wistar rats, which were found to be sensitive to the induction of mesotheliomas with another MMVF.
AIM: The present study is focused on the effect of fiber glass on lung through intratracheal exposure, the analysis of bronchoalveolar lavage and measurement of IL 8 levels, lymphocytes number and histopathological finding after the exposure period.
The animals were divided into three groups of 8 each, exposed to different doses of FG and one control group. The fibers had been size selected to be rat respirable.
Peritoneal Cancer Index (PCI) by diagnostic laparoscopy prior to HIPEC
At the end of the exposure period of 10 weeks the rats were killed one week after the last exposure. Following preparation of the lungs, they were lavaged cancer in peritoneal wall 2x5 ml saline without massage. The lavage fluid was collected in calibrated tubes and harvested volume was recorded.
Supernatant was obtained after centrifugation at 1, r. The second group had the IL8 levels ranging between For the third group the IL8 values ranged between The control group had IL8 values between